With the goals of :
long term low maintenance
efficient energy usage
managing cost vs best practices :

I have read a good bit of the information provided here and on other sites. As most of the information is directed towards the more northern locations – I’m struggling with what to do in my situation – Lower mid TN.
Currently I’m thinking 2×4 walls, fiberglass at R15, 1/2 -3/4 foam on outside, WRB then a good composite siding –
Will be a W/O, mostly facing N/S, lower level  – 3 sided Superior Walls, with the one north facing to the lake  – all stick built.
Most of main level is open concept – about 1400 ftsq, with a dreaded cathedral ceiling in the great room/kitchen area. I have an idea as to how to vent it, and get r-40 or so.
Windows – the longest lead time – probably double pane, low  E-2 but I cannot figure out which manufacturer – Marvin – Pella are leading mostly due to local suppliers.
Will have ERV with good ventilation system – not decided on the HVAC .
I am the builder/GC.  As well as the primary laborer. A few subs involved – framing, foundation, roofing – …
Any ideas or comment welcome.
thanks